|
|
|
 Dominique Broccoli, Ph.D.
Member, Curtis and Elizabeth Anderson Cancer Institute
Department of Laboratory Oncology Research
Professor, Departments of Surgery, Internal Medicine, and Division of Basic Medical Science, Mercer University School of Medicine - Savannah Campus
912-350-0415 (phone)
912-350-1281 (fax)
BroccDo1@memorialhealth.comResearch Focus
Telomere maintenance mechanisms during tumorigenesis in sarcomas. Telomeres are located at the ends of chromosomes and cancer cell immortality requires the active maintenance of these structures. Combining telomere maintenance inhibition with standard therapies may provide a more effective strategy for long-term cancer treatment.
Biography
Dominique Broccoli, Ph.D., leads the cancer biology and genetics program.
She came to Savannah from Fox Chase Cancer Center in Philadelphia. Broccoli
received her undergraduate degree from the University of Nevada-Reno and
her Doctor of Philosophy degree in molecular biology and genetics from
Wayne State University in Detroit. She completed postdoctoral fellowships
at the Western General Hospital in Edinburgh, Scotland, and at the Laboratory
for Cell Biology and Genetics at the Rockefeller University in New York.
Her research has been funded by the American Cancer Society, the Department
of Defense Ovarian Cancer Research Program, and the National Cancer Institute.
She has also received multiple grants for her research. Broccoli has more
than 30 published papers in peer-reviewed research journals. In addition,
she has contributed both reviews and book chapters. She is a permanent
member of the National Institutes of Health study section on molecular
genetics and has served on study sections for the Biologic Sciences Research
Council of the United Kingdom and the Department of Defense Breast Cancer
and Prostate Cancer Research Programs.
Recent Publications
Johnson JE, Broccoli D. Telomere maintenance mechanisms in sarcoma. Curr
Opin Oncol. 2007; in press.
Chen X, Arciero CA, Wang C, Broccoli D, Godwin, AK.
BRCC36 is essential for IR-induced BRCA1 phosphorylation and nuclear foci
formation. Cancer Res. 2006;15:5039-5046.
Johnson JE, Varkonyi RJ, Schwalm, J Cragle R, Klein-Szanto
A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D. Multiple mechanisms
of telomere maintenance exist in liposarcomas. Clin Cancer Res.
2005.
Lewis NL, Mullaney M, Mangan KF, Klumpp T, Rogatko A,
Broccoli D. Measurable immune dysfunction and telomere attrition in long-term
allogeneic transplant recipients. Bone Marrow Transplant. 2004;33:71-78.
Ibanez de Caceres I, Frolova N, Varkonyi RJ, Dulaimi
E, Meropol NJ, Broccoli D, Cairns P. Telomerase is frequently activated
in tumors with microsatellite instability. Cancer Biol Ther. 2004;3:289-292.
|
|