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	Dominique Broccoli, Ph.D. Member, Curtis and Elizabeth Anderson Cancer Institute Department of Laboratory Oncology Research Professor, Departments of Surgery, Internal Medicine, and Division of Basic Medical Science, Mercer University School of Medicine - Savannah Campus 912-350-0957 (phone) 912-350-1281 (fax) BroccDo1@memorialhealth.com

Research Focus
Telomere maintenance mechanisms during tumorigenesis in sarcomas. Telomeres are located at the ends of chromosomes and cancer cell immortality requires the active maintenance of these structures. Combining telomere maintenance inhibition with standard therapies may provide a more effective strategy for long-term cancer treatment.

Biography
Dominique Broccoli, Ph.D., leads the cancer biology and genetics program. She came to Savannah from Fox Chase Cancer Center in Philadelphia. Broccoli received her undergraduate degree from the University of Nevada-Reno and her Doctor of Philosophy degree in molecular biology and genetics from Wayne State University in Detroit. She completed postdoctoral fellowships at the Western General Hospital in Edinburgh, Scotland, and at the Laboratory for Cell Biology and Genetics at the Rockefeller University in New York. Her research has been funded by the American Cancer Society, the Department of Defense Ovarian Cancer Research Program, and the National Cancer Institute. She has also received multiple grants for her research. Broccoli has more than 30 published papers in peer-reviewed research journals. In addition, she has contributed both reviews and book chapters. She is a permanent member of the National Institutes of Health study section on molecular genetics and has served on study sections for the Biologic Sciences Research Council of the United Kingdom and the Department of Defense Breast Cancer and Prostate Cancer Research Programs.

Recent Publications
Johnson JE, Broccoli D. Telomere maintenance mechanisms in sarcoma. Curr Opin Oncol. 2007; in press.

Chen X, Arciero CA, Wang C, Broccoli D, Godwin, AK. BRCC36 is essential for IR-induced BRCA1 phosphorylation and nuclear foci formation. Cancer Res. 2006;15:5039-5046.

Johnson JE, Varkonyi RJ, Schwalm, J Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D. Multiple mechanisms of telomere maintenance exist in liposarcomas. Clin Cancer Res. 2005.

Lewis NL, Mullaney M, Mangan KF, Klumpp T, Rogatko A, Broccoli D. Measurable immune dysfunction and telomere attrition in long-term allogeneic transplant recipients. Bone Marrow Transplant. 2004;33:71-78.

Ibanez de Caceres I, Frolova N, Varkonyi RJ, Dulaimi E, Meropol NJ, Broccoli D, Cairns P. Telomerase is frequently activated in tumors with microsatellite instability. Cancer Biol Ther. 2004;3:289-292.